Science Foundation

From the lineage of a Nobel laureate laboratory, through 36 peer-reviewed papers,
to clinical-stage regenerative medicine pipelines — science is the only language tiptop speaks.

Research Lineage

George Palade LaboratoryFather of Cell BiologyUCSD · 1974 Nobel Prize in Physiology/Medicine (nuclear pore complex, cellular secretion)
Zuo LabDirect successor of the George Palade lineage

Focused on organ regeneration mechanisms, Zuo Lab established a complete research framework from basic cell biology to translational medicine. They discovered multiple tissue-specific stem cell markers and microenvironmental regulation mechanisms, providing the critical molecular foundation for regenerative medicine.

tiptop36 peer-reviewed papers · 5 clinical pipelines · Global raw material standards

Translating over four decades of fundamental research from Nobel-laureate laboratories into market-ready regenerative science products and platforms. From lab to industry, from basic to applied — tiptop is the commercial extension and validation of this academic lineage.

Scientific Network

Frank McKeon

Molecular Genetics

Stem cell & regeneration research

Christopher Crum

Pathology

Tissue regeneration & pathology

Wa Xian

Stem Cell Biology

Alveolar regeneration & organoids

36 Papers · 5 Organ Systems

LungNature 2015 (DOI: 10.1038/nature13903) et al.
12
KidneyIncludes REGEND003 renal pipeline
6
UterusFemale reproductive system regeneration
8
FoundationRegenerative foundation mechanisms
3
OtherLiver, pancreas, cornea, etc.
7

REGEND Clinical Pipeline

Phase II/III

REGEND001

COPD (Chronic Obstructive Pulmonary Disease) cell therapy

FDA Orphan Drug Designation

Targeting airway regeneration and alveolar repair for COPD patients. The first pulmonary regenerative cell therapy product to receive FDA ODD.

Preclinical/Early

REGEND003

Renal failure cell therapy

Targeting nephron regeneration and functional repair in chronic renal failure patients.