Global Compliance & Sovereignty

From INCI to JCIA, from GESS to GMP —
every standard is the final confirmation of safety and quality.

INCI Exclusive Registration

39006Exosome Material A
INCI Exclusive Registration
37568Exosome Material B
INCI Exclusive Registration

JCIA Exclusive Listing

22788Cosmetic Ingredient
JCIA First Registration
22787Cosmetic Ingredient
JCIA First Registration

GESS Global Standard

The Global Exosome Safety Standard (GESS) is the world's first comprehensive safety evaluation standard system specifically for exosome raw materials.

It covers the entire supply chain: raw material source, production process, quality control, stability assessment, and safety toxicology evaluation. tiptop is a core contributor to the GESS standard and among the first to hold its compliance certification.

Compliance Boundaries — Four New Ingredient Registration Paths

JapanJCIA / MHLW

New cosmetic ingredient registration (JCIA first registration numbers obtained)

ChinaNMPA

New ingredient registration (INCI listing followed by China-specific safety evaluation)

GlobalINCI / PCPC

INCI Monograph ID registration (international identifier for cosmetic ingredients)

GESSGlobal Exosome Safety Standard

Global standard for exosome safety, covering manufacturing, quality, and safety evaluation across the entire supply chain.